Tibolone and breast cancer

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N Livial, a finding so pronounced the researchers said they stopped the trial six months early. The hormone, known generically as tibolone and marketed mostly in Europe, is licensed in 90 countries to ease the hot flushes, night sweats and bone loss associated with menopause, while 55 countries have approved it for osteoporosis, according to the study published in the journal Lancet Oncology. Many breast cancer patients currently use the drug for menopause symptoms, but the findings show doctors should not prescribe the medicine to cancer survivors, Peter Kenemans of the VU University Medical Centre in Amsterdam and colleagues said.

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Hormones have an important role in our bodies. They play a role in controlling things like growth, fertility and our mood. After the menopause, the ovaries stop producing the female sex hormone oestrogen.

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The effect of tibolone on breast tissue is still obscure. In vitro studies have shown conflicting results regarding the effects of tibolone on breast cells. On the other hand, although epidemiological studies show an increase in the risk of breast cancer among women treated with tibolone, accumulation of data obtained from radiological studies presents promising results.

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Healthy living, herbal and complementary therapies including herbs and phytoestrogensmenopausal hormone therapy, or MHT formerly called hormone replacement therapy, or HRTor some non-hormonal prescription medications may assist with symptoms. Pharmacy-compounded hormone therapy is also discussed. Many women cope with mild menopausal symptoms and don't need to take any medication or use therapies. Some women manage their symptoms well with lifestyle measures such as eating well and getting regular physical activity.

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Jump to navigation. Cochrane review authors aimed to evaluate the effectiveness and safety of tibolone for treatment of postmenopausal and perimenopausal women. Tibolone is an available option for the treatment of menopausal symptoms, and short-term data suggest its efficacy.

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AMS Tibolone as menopausal hormone therapy Tibolone is a synthetic steroid molecule which is, in essence, a progestogen. Post absorption, its metabolites have oestrogenic, progestogenic and androgenic properties 1, 2.

A subgroup of women was entered into a study of bone mineral density BMD. Women with surgically excised primary BC T, N, M-0 within the last 5 years, complaining of vasomotor symptoms, were assigned to tibolone, 2. In the bone substudy, of women were eligible allocated to tibolone, andto placebo.

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These results were recently published in the New England Journal of Medicine. Historically, women have often been treated with hormone-replacement therapy HRT in order to reduce menopausal symptoms. However, research has emerged indicating that HRT is associated with an increased risk of breast cancer. Since these studies have been published, the use of HRT has decreased dramatically.

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Do not perform sentinel lymph node biopsy SLNB routinely in patients with a preoperative diagnosis of ductal carcinoma in situ DCIS who are having breast conserving surgery, unless they are considered to be at a high risk of invasive disease. Do not offer further axillary treatment to patients found to have only isolated tumour cells in their sentinel lymph nodes. These patients should be regarded as lymph node-negative.

There are various forms and combinations of HRT. This position statement has two sections — a synopsis of evidence to date about the use of HRT and breast cancer risk, and recommendations based on this evidence. The evidence considered in this statement relates to populations of women.

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